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In 1988, the principal target of these antibodies was identified by Swedish internist F Anders Karlsson and colleagues as the acid-producing H+/ K+-adenosine triphosphatase (ATPase) in the cell membrane of gastric parietal cells (125)

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It contains an N-terminal Phox (PX) domain with dual protein/phosphoinositide-binding capacity and a C-terminal Bin/Amphiphysin/Rvs (BAR) domain enabling dimerization with other SNX BAR domains 21